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Von Willebrand’s Disease Type 2 (VWD2)

Von Willebrand Disease Type 2 (VWD2)

Pseudohemophilia, Vascular Hemophilia, Von Willebrand Disease II, Von Willebrand's disease

Von Willebrand disease (vWD) is a genetic disorder that prevents normal blood clotting and can cause extended bleeding following injury. The disorder results from a deficiency or lack of sufficient von Willebrand factor (vWf) which functions as a binding protein during blood clotting. Three types of vWD have been identified in dogs to date and are known as vWD types 1, 2, and 3. Within these three types, there are five different genetic mutations that are currently known that lead to canine vWD. Von Willebrand disease type 2 (VWD2) disease can result in a dog that displays a normal level of von Willebrand factor protein production but with reduced protein function that can lead to blood clotting complications.

Reading Your Results


These dogs have two copies of the normal gene and will neither develop von Willebrand Disease Type 2 nor pass this mutation to their offspring.


These dogs have one copy of the normal gene and one copy of the mutation associated with this disease. They will not develop von Willebrand Disease Type 2 but will, if bred, pass the mutation to 50% of its offspring, on average.


These dogs have two copies of the mutation associated with von Willebrand Disease Type 2 and are susceptible to developing difficulties with blood clotting.

Additional Details


Autosomal Recessive

Affected gene



Ch. 27


Chr27:38887211 (CanFam3): T/G


van Dongen AM, van Leeuwen M, Slappendel RJ. Canine von Willebrand’s disease type 2 in German wirehair pointers in the Netherlands. Vet Rec. 2001 Jan 20; 148(3):80-2. [PubMed: 12503596]