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T-Locus (T-LOCUS)

T Locus (T-LOCUS)

T Locus (Natural Bobtail), Natural Bobtail Trait

The T Locus mutation affects a gene involved in natural tail length development. If present, the mutation can disrupt the development of the dog’s tail which can result in a naturally short tail also known as a “bobtail”. This mutation is inherited in a dominant fashion which means only one copy of the mutation is required to produce a natural bobtail. It is important to note that a dog that inherits two copies of the T Locus mutation will likely not survive the development process which can result in reduced litter sizes.

Reading Your Results

A. (CLEAR/NORMAL):

These dogs have two copies of the normal gene and will neither develop a naturally short tail due to the T Locus mutation nor pass this mutation to their offspring.

B. (CARRIER/AFFECTED):

These dogs have one copy of the normal gene and one copy of the mutation associated with a naturally short tail. They will develop a naturally short tail and will, if bred, pass the mutation to 50% of its offspring, on average.

C. (AT RISK/AFFECTED):

These dogs have two copies of the mutation associated with a naturally short tail which can lead to reduced survival rates in utero. These dogs will typically not survive the development process.

Additional Details

Inheritances

Autosomal Dominant

Affected gene

T

Chromosome

Ch. 1

Mutation

Chr1:54192143 (CanFam3): C>G

Publication:

Hytonen MK, Grall A, Hedan B, Dreano S, Seguin SJ, Delattre D, Thomas A, Galibert F, Paulin L, Lohi H, Sainio K, Andre C. Ancestral T-box mutation is present in many, but not all, short-tailed dog breeds. J Hered. 2009 Mar-Apr; 100(2):236-40. [PubMed: 18854372]