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Neonatal Encephalopathy (NE)

Neonatal Encephalopathy (NE)

Neonatal Encephalopathy with Seizures, NEWS, Neonatal Encephalopathy (Poodle Type)

Neonatal Encephalopathy (NE) also known as Neonatal Encephalopathy with Seizures (NEWS) is a recessive developmental brain disease. Affected pups exhibit extreme weakness, and those that survive the first week generally develop progressively worse ataxia, or inability to move properly. This is often accompanied by severe seizures. Affected puppies typically don’t survive beyond about 7 weeks of age.

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These dogs have two copies of the normal gene and will neither develop Neonatal Encephalopathy nor pass this mutation to their offspring.


These dogs have one copy of the normal gene and one copy of the mutation associated with this disease. They will not develop Neonatal Encephalopathy but will, if bred, pass the mutation to 50% of its offspring, on average.


These dogs have two copies of the mutation associated with Neonatal Encephalopathy which results in ataxia and poor survival beyond 7 weeks of age.

Additional Details


Autosomal Recessive

Affected gene



Ch. 36


Missense C.152T>G


Chen X, Johnson GS, Schnabel RD, Taylor JF, Johnson GC, Parker HG, Patterson EE, Katz ML, Awano T, Khan S, O’Brien DP. A neonatal encephalopathy with seizures in standard poodle dogs with a missense mutation in the canine ortholog of ATF2. Neurogenetics. 2008 Feb; 9(1):41-9. [PubMed: 18074159]