Hyperuricosuria (HU)
Urolithiasis, HUU
This disease is characterized by the excretion of uric acid leading to the formation of urinary calculi (stones) which may then require surgery. If a dog from a breed susceptible to this disorder is seen to experience problems urinating freely, then veterinary advice should be sought immediately.
Reading Your Results
A. (CLEAR/NORMAL):
These dogs have two copies of the normal gene and will neither develop urate stone disorder nor pass this mutation to their offspring.
B. (CARRIER/NOT AFFECTED):
These dogs have one copy of the normal gene and one copy of the mutation associated with this disease. They will not develop urate stone disorder but will, if bred, pass the mutation to 50% of its offspring, on average.
C. (AT RISK/AFFECTED):
These dogs have two copies of the mutation associated with this disease and are susceptible to developing bladder/kidney stones.
Recommended For:
- Alapaha Blue Blood Bulldog
- Altman White English Bulldog
- American Bulldog
- American Pit Bull Terrier
- American Staffordshire Terrier
- Australian Shepherd
- Berger Blanc Suisse
- Biewer Terrier
- Black Russian Terrier
- Boerboel
- Boston Terrier
- Bulldog
- Catahoula Leopard Dog
- Coton De Tulear
- Dalmatian
- Danish-Swedish Farmdog
- English Bulldog
- English Mastiff
- English Shepherd
- French Bulldog
- German Longhaired Pointer
- German Shepherd Dog
- German Shorthaired Pointer
- Giant Schnauzer
- Greater Swiss Mountain Dog
- Hungarian Wirehaired Vizsla
- Jack Russell Terrier
- Jagdterrier
- Kromfohrlander
- Lagotto Romagnolo
- Large Munsterlander
- Mastiff
- Miniature American Shepherd
- Miniature Australian Shepherd
- Miniature Schnauzer
- North American Shepherd
- Olde English Bulldogge
- Parson Russell Terrier
- Pitbull
- Pomeranian
- Russell Terrier
- Shiloh Shepherd
- Siberian Indian Dog
- Small Munsterlander
- South African Boerboel
- Standard Schnauzer
- Swedish Vallhund
- Swiss Mountain Dog
- Toy Australian Shepherd
- Urogenital
- Vizsla
- Weimaraner
- White English Bulldog
- White Shepherd
- Wirehaired Vizsla
- Yorkshire Terrier
Additional Details
Inheritances
Autosomal Recessive
Affected gene
SLC2A9
Chromosome
Ch. 3
Mutation
C.563G>T
Publication:
Bannasch D, Safra N, Young A, Karmi N, Schaible RS, Ling GV. Mutations in the SLC2A9 gene cause hyperuricosuria and hyperuricemia in the dog. PLoS Genet. 2008 Nov;4(11):e1000246. [PubMed: 18989453]