Hyperuricosuria (HU)

Urolithiasis, HUU

This disease is characterized by the excretion of uric acid leading to the formation of urinary calculi (stones) which may then require surgery. If a dog from a breed susceptible to this disorder is seen to experience problems urinating freely, then veterinary advice should be sought immediately.

Reading Your Results

A. (CLEAR/NORMAL):

These dogs have two copies of the normal gene and will neither develop urate stone disorder nor pass this mutation to their offspring.

B. (CARRIER/NOT AFFECTED):

These dogs have one copy of the normal gene and one copy of the mutation associated with this disease. They will not develop urate stone disorder but will, if bred, pass the mutation to 50% of its offspring, on average.

C. (AT RISK/AFFECTED):

These dogs have two copies of the mutation associated with this disease and are susceptible to developing bladder/kidney stones.

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Additional Details

Inheritances

Autosomal Recessive

Affected gene

SLC2A9

Chromosome

Ch. 3

Mutation

C.563G>T

Publication:

Bannasch D, Safra N, Young A, Karmi N, Schaible RS, Ling GV. Mutations in the SLC2A9 gene cause hyperuricosuria and hyperuricemia in the dog. PLoS Genet. 2008 Nov;4(11):e1000246. [PubMed: 18989453]

Hyperuricosuria (HU)