Hereditary Nasal Parakeratosis (HNPK)
Hereditary Nasal Parakeratosis (Labrador Retriever Type)
Hereditary Nasal Parakeratosis (HNPK) is a disease that affects Labrador Retrievers and related breeds and leads to dry, rough, discolored crusts on the edges of the dog’s nose. The disease results from a mutation that causes the nose to dry out and can lead to chronic irritation and inflammation of the skin on and surrounding the dog’s nose. Symptoms of the disorder appear in young dogs typically between the ages of around 6 months to 1 year of age. In more severe cases of the disease, cracked skin around and on the tip of the nose can become infected and require medical attention. In later stages, the disease can also affect nose pigmentation with nose skin color changing from dark to lighter shades of color. Once diagnosed, continuous care is required to reduce the occurrence of crusting on and around the dog’s nose using topical treatments.
Reading Your Results
A. (CLEAR/NORMAL):
These dogs have two copies of the normal gene and will neither develop Hereditary Nasal Parakeratosis nor pass this mutation to their offspring.
B. (CARRIER/NOT AFFECTED):
These dogs have one copy of the normal gene and one copy of the mutation associated with this disease. They will not develop Hereditary Nasal Parakeratosis but will, if bred, pass the mutation to 50% of its offspring, on average.
C. (AT RISK/AFFECTED):
These dogs have two copies of the mutation associated with Hereditary Nasal Parakeratosis which results in discolored crusts on the edges of the dog’s nose that can become infected and require further treatment.
Additional Details
Inheritances
Autosomal Recessive
Affected gene
SUV39H2
Chromosome
Ch. 2
Mutation
C.972T>G
Publication:
Jagannathan V, Bannoehr J, Plattet P, Hauswirth R, Drogemuller C, Drogemuller M, Weiner DJ, Doherr M, Owczarek-Lipska M, Galichet A, Welle MM, Tengvall K, Bergvall K, Lohi H, Rufenacht S, Linek M, Paradis M, Muller EJ, Roosje P, Leeb T. A mutation in the SUV39H2 gene in Labrador retrievers with hereditary nasal parakeratosis (HNPK) provides insights into the epigenetics of keratinocyte differentiation. PLoS Genet. 2013;9(10):e1003848. doi: 10.1371/journal.pgen.1003848. Epub 2013 Oct 3. [PubMed: 24098150]
