Exercise Induced Collapse (EIC)
Exercise-Induced Collapse
Exercise Induced Collapse (EIC) is a canine genetic disorder that leads to loss of muscle control following periods of extreme exercise. Episodes generally occur after 5-25 minutes of excessive activity that can include actively running for extended periods of time. Episode severity ranges between different dogs and often begins with a form of rocking followed by weakening of the hind limbs and eventual collapse. Attacks are typically brief (less than 20 minutes) and dogs tend to recover. In a limited number of cases, episodes can be fatal. Affected dogs begin to show symptoms from a couple of months to 3 years of age and are more susceptible at an age when more intensive training begins. It is important for owners of dogs affected by EIC to be familiar with activities that may trigger an episode.
Reading Your Results
A. (CLEAR/NORMAL):
These dogs have two copies of the normal gene and will neither develop Exercise Induced Collapse nor pass this mutation to their offspring.
B. (CARRIER/NOT AFFECTED):
These dogs have one copy of the normal gene and one copy of the mutation associated with this disease. They will not develop Exercise Induced Collapse but will, if bred, pass the mutation to 50% of its offspring, on average.
C. (AT RISK/AFFECTED):
These dogs have two copies of the mutation associated with Exercise Induced Collapse and are susceptible to collapsing following periods of extreme exercise.
Recommended For:
- American Cocker Spaniel
- Australian Labradoodle
- Bouvier des Flanders
- Bouvier des Flandres
- Boykin Spaniel
- Cardigan Welsh Corgi
- Chesapeake Bay Retriever
- Clumber Spaniel
- Cockapoo
- Cocker Spaniel
- Corgi
- Curly-Coated Retriever
- English Cocker Spaniel
- German Longhaired Pointer
- German Wirehaired Pointer
- Hungarian Wirehaired Vizsla
- Labradoodle
- Labrador Retriever
- Neurology
- Old English Sheepdog
- Pekingese
- Pembroke Welsh Corgi
- Vizsla
- Wirehaired Vizsla
Additional Details
Inheritances
Autosomal Recessive
Affected gene
DNM1
Chromosome
Ch. 9
Mutation
C.767G>T
Publication:
Patterson EE, Minor KM, Tchernatynskaia AV, Taylor SM, Shelton GD, Ekenstedt KJ, Mickelson JR. A canine DNM1 mutation is highly associated with the syndrome of exercise-induced collapse. Nat Genet. 2008 Oct; 40(10):1235-9. [PubMed: 18806795]
