Chondrodystrophy And IVDD Risk (CDDY-IVDD)
Intervertebral Disc Disease, CDDY with IVDD, Hansen's Type I IVDD
Many dog breeds are defined by the presence of shortened legs that result from abnormal growth of cartilage and changes in the structure of growth plates. This leads to shortened leg bones that exhibit a bowed appearance. Two conditions have been described that cause shortened legs and are known as Chondrodysplasia (CDPA) and Chondrodystrophy (CDDY).
The CDDY-IVDD mutation leads to shortened legs but more importantly, can also put a dog at risk for premature degeneration of intervertebral discs known as Intervertebral Disc Disease (IVDD). The intervertebral disc sits between the vertebrae and allows for flexibility of the vertebral column. In dogs that carry the CDDY mutation, premature calcification can lead to the degeneration of discs in dogs at a young age resulting in herniation, inflammation, and hemorrhage in the spinal cord. This can ultimately lead to severe pain and neurological dysfunction typical for IVDD.
Reading Your Results
A. (CLEAR/NORMAL):
These dogs have two copies of the normal gene and do not possess the mutation that leads to shortened legs and increased IVDD risk.
B. (CARRIER/AFFECTED):
These dogs have one copy of the normal gene and one copy of the mutation associated with shortened legs and increased IVDD risk. They will have shortened legs and are at risk for IVDD. If bred, these dogs will pass the mutation to 50% of their offspring, on average.
C. (AT RISK/AFFECTED):
These dogs have two copies of the mutation associated with shortened legs and increased IVDD risk. They will have shortened legs and are at risk for IVDD. If bred, these dogs will pass the mutation to 100% of their offspring, on average.
Recommended For:
- Australian Shepherd
- Basset Hound
- Beagle
- Beagle-Harrier
- Bichon Frise
- Cardigan Welsh Corgi
- Cavalier King Charles Spaniel
- Chesapeake Bay Retriever
- Chihuahua
- Chinese Crested
- Chinook
- Coton De Tulear
- Dandie Dinmont Terrier
- Doberman Pinscher
- English Springer Spaniel
- French Bulldog
- Goldendoodle
- Havanese
- Jack Russell Terrier
- Lucas Terrier
- Miniature American Shepherd
- Miniature Australian Shepherd
- Miniature Dachshund
- Miniature Long-Haired Dachshund
- Miniature Pinscher
- Miniature Poodle
- Miniature Rat Terrier
- Miniature Smooth-Haired Dachshund
- Miniature Wire-Haired Dachshund
- Neurology
- Nova Scotia Duck Tolling Retriever
- Pekingese
- Pembroke Welsh Corgi
- Portuguese Water Dog
- Rat Terrier
- Scottish Terrier
- Sealyham Terrier
- Shih Tzu
- Standard Dachshund
- Teddy Roosevelt Terrier
- Toy Poodle
- Yorkshire Terrier
Additional Details
Inheritances
Autosomal Dominant
Affected gene
FGF4L2
Chromosome
Ch. 12
Mutation
3,209 Bp Long Insertion Containing A FGF4 Retrogene
Publication:
Brown EA, Dickinson PJ, Mansour T, Sturges BK, Aguilar M, Young AE, Korff C, Lind J, Ettinger CL, Varon S, Pollard R, Brown CT, Raudsepp T, Bannasch DL. FGF4 retrogene on CFA12 is responsible for chondrodystrophy and intervertebral disc disease in dogs. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11476-11481. doi: 10.1073/pnas.1709082114. [PubMed: 29073074]
