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Canine Multifocal Retinopathy (CMR1)

Canine Multifocal Retinopathy 1 (CMR1)

Multifocal Retinopathy 1, Multifocal Retinopathy

The Canine Multifocal Retinopathy 1 (CMR1) mutation causes raised lesions to form on the retina which alters the appearance of the eye but usually does not affect sight. The lesions may disappear or may result in minor retinal folding. Symptoms usually appear when a puppy is only a few months old, and generally do not worsen over time. The genetic test for CMR1 is valuable for identifying the cause of retinal deformation. Given the exact genetic diagnosis, the owner can be reassured that there probably will be little or no vision loss due to this condition.

Reading Your Results


These dogs have two copies of the normal gene and will neither develop Canine Multifocal Retinopathy nor pass this mutation to their offspring.


These dogs have one copy of the normal gene and one copy of the mutation associated with this disease. They will not develop Canine Multifocal Retinopathy but will, if bred, pass the mutation to 50% of its offspring, on average.


These dogs have two copies of the mutation associated with this disease and are susceptible to developing retinal deformation.

Additional Details


Autosomal Recessive

Affected gene



Ch. 18




Guziewicz KE, Zangerl B, Lindauer SJ, Mullins RF, Sandmeyer LS, Grahn BH, Stone EM, Acland GM, Aguirre GD. Bestrophin gene mutations cause canine multifocal retinopathy: a novel animal model for best disease. Invest Ophthalmol Vis Sci. 2007 May;48(5):1959-67. [PubMed: 17460247]