Canine Leukocyte Adhesion Deficiency (CLAD)
Leukocyte Adhesion Deficiency, LAD-I
Canine Leukocyte Adhesion Deficiency (CLAD) is an inherited condition that is due to abnormal white blood cells or leukocytes that impair the ability of a dog’s immune system to respond to infection. Dogs will typically develop symptoms at less than 12 weeks of age and can include umbilical infection, fever, poor growth, and insufficient wound healing. Additional symptoms can include infection of the gums with salivation and abnormal skin infections. Pathology testing will typically show a high white blood cell count because cells are still produced but are unable to move into the tissue to fight infection. Infections will respond to antibiotics but can reoccur once treatment is stopped so puppies will typically not survive past 6 months of age.
Reading Your Results
A. (CLEAR/NORMAL):
These dogs have two copies of the normal gene and will neither develop Canine Leukocyte Adhesion Deficiency nor pass this mutation to their offspring.
B. (CARRIER/NOT AFFECTED):
These dogs have two copies of the normal gene and will neither develop Canine Leukocyte Adhesion Deficiency nor pass this mutation to their offspring.
C. (AT RISK/AFFECTED):
These dogs have two copies of the normal gene and will neither develop Canine Leukocyte Adhesion Deficiency nor pass this mutation to their offspring.
Additional Details
Inheritances
Autosomal Recessive
Affected gene
ITGB2
Chromosome
Ch. 31
Mutation
C.107G>C
Publication:
Kijas JM, Bauer Jr. TR, Gafvert S, Marklund S, Trowald-Wigh G, Johannisson A, Hedhammar A, Binns M, Juneja RK, Hickstein DD, Andersson L. A Missense mutation in the beta-2 integrin gene (ITGB2) causes canine leukocyte adhesion deficiency. Genomics. 1999 Oct 1;61(1):101-7. [PubMed: 10512685]
