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Canine Factor VII Deficiency (CFVII)

Canine Factor VII Deficiency (CFVII)

Factor VII deficiency, Hypoproconvertinemia

Canine Factor VII Deficiency (CFVII) is a hereditary disease that leads to blood clotting issues. Factor VII is a clotting factor synthesized in the liver that is necessary to initiate blood coagulation when a vascular injury occurs. The condition is not fatal but can cause increased bleeding after surgery or injury in affected dogs. In rare circumstances, an affected dog may experience excessive bleeding and require a blood transfusion.

Reading Your Results


These dogs have two copies of the normal gene and will neither develop Factor VII Deficiency nor pass this mutation to their offspring.


These dogs have one copy of the normal gene and one copy of the mutation associated with this disease. They will not develop Factor VII Deficiency but will, if bred, pass the mutation to 50% of its offspring, on average.


These dogs have two copies of the mutation associated with this disease and are susceptible to developing problems with blood clotting.

Additional Details


Autosomal Recessive

Affected gene



Ch. 22


C.407 G>A


Callan MB, Aljamali MN, Margaritis P, Griot-Wenk ME, Pollak ES, Werner P, Giger U, High KA. A novel missense mutation responsible for factor VII deficiency in research Beagle colonies. J Thromb Haemost. 2006 Dec; 4(12):2616-22. [PubMed: 16961583]