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Border Collie Glaucoma (BCG)

Border Collie Glaucoma (BCG)

Glaucoma (Border Collie Type), Goniodysgenesis, Primary Closed Angle Glaucoma, PCAG

Glaucoma is a painful and potentially blinding disease associated with increased eye pressure that can be caused by an improper eye drainage system. Lack of fluid drainage can lead to increased fluid pressure inside the eye and subsequent damage to the optic nerve potentially leading to a total loss of vision. Symptoms of the disease can include severe pain, light sensitivity, eye spasms, and watery eyes. Dogs suffering from this condition may display behaviors such as hiding, refusal to eat, and defensive head movements in response to painful symptoms. It is important to note that the mutation detected by this test is considered a ‘candidate’ mutation that has been strongly associated with glaucoma in Border Collies and can provide value in assisting with breeding decisions but will require additional research to demonstrate a conclusive connection to the disease.

Reading Your Results


These dogs have two copies of the normal gene and will neither develop BCG nor pass this mutation to their offspring.


These dogs have one copy of the normal gene and one copy of the mutation associated with this disease. They will not develop BCG but will, if bred, pass the mutation to 50% of its offspring, on average.



These dogs have two copies of the mutation associated with this disease which will likely result in eye drainage issues, pressure buildup within the eye and potential loss of vision.

Recommended For:

Additional Details


Autosomal Recessive

Affected gene



Ch. 17


C.590 G>A


Pugh CA, Farrell LL, Carlisle AJ, Bush SJ, Trejo-Reveles V, Matika O, de Kloet A, Walsh C, Bishop SC, Prendergast JGD, Schoenebeck JJ, Rainger J, Summers KM. Arginine to glutamine mutation in olfactomedin-like 3 (OLFML3) is a candidate for severe goniodysgenesis and glaucoma in the Border Collie dog breed. G3 (Bethesda). 2019 Mar 7;9(3):943-954. doi: 10.1534/g3.118.200944. PubMed: 30696701 [PubMed: 30696701]