Bandera’s Neonatal Ataxia (BNAT)
Bandera's syndrome, Neonatal ataxia, Neonatal cerebellar ataxia
Bandera’s Neonatal Ataxia (BNAT) is an early-onset neurologic disease affecting Coton de Tulears. Symptoms present shortly after birth in affected puppies and consist of an inability to balance, stand or walk normally. Other symptoms include difficulties eating or eliminating. Affected puppies tend to scoot on their stomachs and can also fall to their side and paddle their legs. Symptom severity tends to increase over time with affected puppies typically being euthanized due to poor quality of life.
Reading Your Results
A. (CLEAR/NORMAL):
These dogs have two copies of the normal gene and will neither develop BNAT nor pass this mutation to their offspring.
B. (CARRIER/NOT AFFECTED):
These dogs have one copy of the normal gene and one copy of the mutation associated with this disease. They will not develop BNAT but will, if bred, pass the mutation to 50% of its offspring, on average.
C. (AT RISK/AFFECTED):
These dogs have two copies of the mutation associated with this disease which results in ataxia and poor survival beyond a few weeks of age.
Additional Details WIP
Inheritances
Autosomal Recessive
Affected gene
GRM1
Chromosome
Ch. 1
Mutation
62 bp insertion (ins AAGACCCGCAACGT(A)48); 14 bp duplication (AAGACCCGCAACGT)
Publication:
Zeng R, Farias FH, Johnson GS, McKay SD, Schnabel RD, Decker JE, Taylor JF, Mann CS, Katz ML, Johnson GC, Coates JR, O’Brien DP. A truncated retrotransposon disrupts the GRM1 coding sequence in Coton de Tulear dogs with Bandera’s neonatal ataxia. J Vet Intern Med. 2011 Mar-Apr; 25(2):267-72. [PubMed: 21281350]
