Osteochondrodysplasia (OCD)
Skeletal dwarfism
Osteochondrodysplasia (OCD) is an inherited musculoskeletal disorder affecting Standard Poodles, Miniature Poodles, Toy Poodles, and associated breeds. Symptoms for affected dogs will typically present at about 3 weeks of age characterized by stunted growth and abnormal locomotion. Affected puppies will walk differently than unaffected littermates due to the development of abducted or splayed hind limbs and front feet turned out with deformed paws. These dogs can have enlarged joints and clubbed feet with short, bent legs. Additionally, these dogs may exhibit flattened rib cages and under-bites that can affect their ability to nurse or breathe. With supportive care, affected dogs can survive for several years but will likely develop arthritis and breathing difficulty due to a deformed rib cage.
Reading Your Results
A. (CLEAR/NORMAL):
These dogs have two copies of the normal gene and will neither develop Osteochondrodysplasia nor pass this mutation to their offspring.
B. (CARRIER/NOT AFFECTED):
These dogs have one copy of the normal gene and one copy of the mutation associated with this disease. They will not develop Osteochondrodysplasia but will, if bred, pass the mutation to 50% of its offspring, on average.
C. (AT RISK/AFFECTED):
These dogs have two copies of the mutation associated with Osteochondrodysplasia and are likely to develop skeletal issues including splayed and shorter limbs, flattened rib cages, and under-bites.
Additional Details
Inheritances
Autosomal Recessive
Affected gene
SLC13A1
Chromosome
Ch. 14
Mutation
C.60628771-60758561 (CanFam3): 129,790 Bp Deletion
Publication:
Neff MW, Beck JS, Koeman JM, Boguslawski E, Kefene L, Borgman A, Ruhe AL. Partial deletion of the sulfate transporter SLC13A1 is associated with osteochondrodysplasia in the Miniature Poodle breed. PLoS One. 2012;7(12):e51917. [PubMed: 23300579]
