Progressive Rod-Cone Degeneration (PRA-PRCD)
Progressive retinal atrophy (PRA) is a category of different progressive conditions related to retinal atrophy that can eventually lead to blindness. Progressive rod-cone degeneration (PRA-PRCD) is one specific type of PRA that affects many dog breeds. It is an inherited eye disease with late onset of symptoms that are due to degeneration of both rod and cone cells of the retina. These cells are important for vision in dim and bright light. Most dogs begin to show symptoms of the disease at approximately 3-5 years of age that manifests as difficulty seeing at night (night blindness) and loss of peripheral vision. Although rate of onset and disease progression can vary by breed, PRA-PRCD typically results in eventual loss of sight and complete blindness in affected dogs. It is important to note that other inherited eye disorders can display similar symptoms to PRA-PRCD.
American Eskimo Dog
Australian Cattle Dog
Australian Stumpy Tail Cattle Dog
Chesapeake Bay Retriever
Coton De Tulear
English Cocker Spaniel
Entlebucher Mountain Dog
Karelian Bear Dog
Miniature American Shepherd
Miniature Australian Shepherd
Nova Scotia Duck Tolling Retriever
Portuguese Water Dog
Spanish Water Dog
Toy Australian Shepherd
A (CLEAR/NORMAL): These dogs have two copies of the normal gene and will neither develop PRA-PRCD nor pass this mutation to their offspring.
B (CARRIER/NOT AFFECTED): These dogs have one copy of the normal gene and one copy of the mutation associated with this disease. They will not develop PRA-PRCD and will, if bred, pass the mutation to 50% of its offspring, on average.
C (AT RISK/AFFECTED): These dogs have two copies of the mutation associated with PRA-PRCD which typically results in complete blindness for most breeds.
Progressive Rod‑Cone Degeneration (PRA‑PRCD)
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