Primary Lens Luxation (PLL) Genetic Test | GenSol Diagnostics
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Primary Lens Luxation (PLL)


The lens of the eye normally lies immediately behind the iris and the pupil, and is suspended in place by a series of fibers.  It functions to focus light rays on the retina, in the back of the eye. When partial or complete breakdown of these fibers occur, the lens may become partially or fully dislocated from its normal position.   Lens luxation can occur for several different reasons.  Primary lens luxation is a heritable disease in many breeds and spontaneous luxation of the lens occurs in early adulthood (most commonly 3-6 years of age) and often affects both eyes, although not necessarily at the same time.  Lens luxation can lead to inflammation and glaucoma that can result in painful, teary, red eyes that may look hazy or cloudy. If detected early, surgical removal of the lens can be beneficial. Medical treatment of inflammation and glaucoma in the form of topical and oral medications can relieve much of the discomfort associated with this disease.

American Eskimo Dog
American Hairless (Rat) Terrier
Australian Cattle Dog
Chinese Crested
Chinese Foo Dog
Jack Russell Terrier
Jagd Terrier
Lakeland Terrier
Lancashire Heeler
Lucas Terrier
Miniature Bull Terrier
Norfolk Terrier
Norwich Terrier
Parson Russell Terrier
Rat Terrier
Russell Terrier
Sealyham Terrier
Tenterfield Terrier
Tibetan Terrier
Toy Fox Terrier
Volpino Italiano
Welsh Terrier
Yorkshire Terrier

A (CLEAR/NORMAL): These dogs have two normal copies of DNA. Research has demonstrated clear dogs will not develop PLL as a result of the mutation, although it is possible they might develop PLL due to other causes, such as trauma or the effects of other, unidentified mutations.

B (CARRIER/NOT AFFECTED): These dogs have one copy of the mutation and one normal copy of DNA. Research has demonstrated that carriers have a very low risk of developing PLL. The majority of carriers do not develop PLL during their lives but a small percentage do. Current estimates are that between 2% – 20% of carriers will develop the condition.

C (AT RISK/AFFECTED): These dogs have two copies of the mutation and will almost certainly develop PLL during their lifetime. It is advised that all genetically affected dogs have their eyes examined by a veterinary ophthalmologist every 6 months, from the age of 18 months, so the clinical signs of PLL are detected as early as possible.

Primary Lens Luxation (PLL)

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