Collie Eye Anomaly (CEA) Genetic Test | GenSol Diagnostics
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Collie Eye Anomaly (CEA)


Collie eye anomaly (CEA) is an inherited disease that affects several dog breeds.  It can also be referred to as choroidal hypoplasia (CH) due to the fact that the choroid layer of tissue is thinner in dogs suffering from the disease.  This layer of tissue is responsible for supplying nutrients and blood to the retina.  With insufficient blood flow the choroid does not develop properly and can often lead to retinal detachment and subsequent blindness.  The disease can present itself in both a mild and severe form with symptoms varying between affected dogs.  Dogs with a mild form of the disease can show thinning of the choroid and may maintain normal vision.  Dogs with a more severe version of the disease can have additional eye problems leading to significant vision loss and potentially complete blindness. Although both mild and severe forms of CEA are associated with the same mutation (NHEJ1), predicting disease severity is difficult.

Australian Shepherd
Bearded Collie
Border Collie
Boykin Spaniel
English Shepherd
Lancashire Heeler
Longhaired Whippet
Miniature American Shepherd
Miniature Australian Shepherd
Nova Scotia Duck Tolling Retriever
Rough Collie
Shetland Sheepdog
Silken Windhound
Smooth Collie
Toy Australian Shepherd

A (CLEAR/NORMAL): These dogs have two copies of the normal gene and will neither develop CEA nor pass this mutation to their offspring.

B (CARRIER/NOT AFFECTED): These dogs have one copy of the normal gene and one copy of the mutation associated with this disease. They will not develop CEA and will, if bred, pass the mutation to 50% of its offspring, on average.

C (AT RISK/AFFECTED): These dogs have two copies of the mutation associated with CEA which can result in a range of symptoms from vision impairment to complete blindness.

Collie Eye Anomaly (CEA)

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