Canine Multifocal Retinopathy (CMR1)
The canine multifocal retinopathy mutation causes raised lesions to form on the retina which alters the appearance of the eye but usually does not affect sight. The lesions may disappear or may result in minor retinal folding. Symptoms of the mutation usually appear when a puppy is only a few months old, and generally do not worsen over time. The genetic test for CMR is valuable for identifying the cause of retinal deformation. Given the exact genetic diagnosis, the owner can be reassured that there probably will be little or no vision loss due to this condition.
While both CMR1 and CMR2 mutations are in the same gene, they are breed specific and testing for only one is required. The CMR2 mutation is specific for the Coton de Tulear breed. All other breeds listed should test for the CMR1 mutation.
- Alapaha Blue Blood Bulldog
- American Bulldog
- Australian Shepherd
- Cane Corso (AKA Italian Mastiff)
- Dogue de Bordeaux
- English Bulldog
- English Mastiff
- Great Pyrenees
- Perro de Presa Canario
A (CLEAR/NORMAL): These dogs have two copies of the normal gene and will neither develop CMR disorder nor pass this mutation to their offspring.
B (CARRIER/NOT AFFECTED): These dogs have one copy of the normal gene and one copy of the mutation associated with this disease. They will not develop CMR disorder but will, if bred, pass the mutation to 50% of its offspring, on average.
C (AT RISK/AFFECTED): These dogs have two copies of the mutation associated with this disease and are susceptible to develop retinal deformation.