A-Ay Locus (A-AY-LOCUS)
The A Locus (agouti series) interacts closely with the E, K, and B Loci that can lead to a dog’s overall coat color and pattern. A Locus mutations are only expressed if the dog is “Clear” or “Carrier” at the E locus and “Clear” at the K-KB locus. There are three potential mutations at the A Locus that can each have a different effect on coat color. The mutations are known as A-ay, A-at and A-a and can determine whether a dog is a Carrier of sable/fawn, black and tan/tricolor/tan points coloration or a recessive form of a solid black or bicolor coat color.
The A-ay gene mutation produces a coat color that can range from a light fawn to darker red to a sable based on variation in gene expression. For dogs that are “Clear” at the K-KB Locus and have one or two copies of the A-ay mutation will always express a sable/fawn coat color. This means a dog that appears fawn or sable can carry any of the other A-locus alleles (A-at, A-a or A-aw) and would not express them. The A-Locus alleles are expressed in a hierarchical manner with A-ay being dominant to and expressed over A-aw, A-at and A-a. A-aw is the next most dominant mutation followed by A-at and the least dominant mutation, A-a. It is important to note that the dog’s coat color is also dependent on the dog’s genotypes at E, K, and B Locus among others.
A (CLEAR/NORMAL): These dogs have two copies of the normal gene and the effect of A Locus on their coat color can be determined by testing at the A-at and A-a loci. They will also not pass this mutation to any of their offspring.
B (CARRIER/AFFECTED): These dogs have one copy of the normal gene and one copy of the mutation associated with sable/fawn coat color. They will exhibit a sable/fawn coat color. The effects of A Locus on offspring coat color can be determined by testing at the A-at and A-a loci. They will, if bred, pass the mutation to 50% of their offspring, on average.
C (AT RISK/AFFECTED): These dogs have two copies of the mutation and will develop a sable/fawn coat color due to the A-ay locus mutation and will pass this mutation to 100% of their offspring. However, this dog’s coat color is also dependent on the E, K, and B Locus genes.
A‑Ay Locus (A‑AY‑LOCUS)
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