GenSol is now offering Brachycephaly (BR-BMP3). This is a skull shape trait seen in a number of breeds and is characterized by a shortened head, pushed in face, and typically an underbite with widely spaced shallow orbits. Breeds known to exhibit this trait include Pugs, Boxers, Bulldogs and Boston Terriers. The overall shape and size of a dog’s skull is likely the result of multiple genetic factors with a mutation in the BMP3 gene being one factor contributing to a short muzzle. BMP3 is also suspected to be essential for normal craniofacial development with mutations in this gene likely leading to abnormal craniofacial development. This
mutation is typically fixed or carried in two copies in breeds such as Pug, Pekingese, French Bulldog, Brussels Griffon and Boston Terriers. Additional mutations such as SMOC2 are currently being studied to determine their effect on skull development and brachycephaly. While BR-BMP3 is commonly found in the breeds mentioned above, this is not a breed-specific test and can be performed on any breed to identify the presence of this mutation.
Direct Link to our New Brachycephaly Test
Other Helpful Information for Brachycephaly
- VCA Animal Hospital – Brachycephaly
- AKC – A Guide to Flat-Faced Dogs
- American College of Veterinary Surgeons
