Canine Leukocyte Adhesion Deficiency (CLAD) is an inherited condition that is due to abnormal white blood cells or leukocytes that impair the ability of a dog’s immune system to respond to infection. Dogs will typically develop symptoms at less than 12 weeks of age and can include umbilical infection, fever, poor growth and insufficient wound healing. Additional symptoms can include infection of the gums with salivation and abnormal skin infections. Pathology testing will typically show a high white blood cell count because cells are still produced but are unable to move into tissue to fight infection. Infections will respond to antibiotics but can reoccur once treatment is stopped so puppies will typically die by 6 months of age.