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Collie Eye Anomaly (CEA)
Collie eye anomaly (CEA) is an inherited disease that affects several dog breeds. It can also be referred to as choroidal hypoplasia (CH) due to the fact that the choroid layer of tissue is thinner in dogs suffering from the disease. This layer of tissue is responsible for supplying nutrients and blood to the retina. With insufficient blood flow the choroid does not develop properly and can often lead to retinal detachment and subsequent blindness. The disease can present itself in both a mild and severe form with symptoms varying between affected dogs. Dogs with a mild form of the disease can show thinning of the choroid and may maintain normal vision. Dogs with a more severe version of the disease can have additional eye problems leading to significant vision loss and potentially complete blindness. Although both mild and severe forms of CEA are associated with the same mutation (NHEJ1), predicting disease severity is difficult.